I did try the EF 2x on the 100-400II but to slow and to much quality loss. Only got the RF 2x after I got the 400 2.8, not yet tried on the 100-500.
I was wondering. If the 2x would perform well on the RF 100-500 I might buy it too. But I fear I won't do as well as on your 400mm prime.
 
White Stork. (Or grubby stork, if you prefer!.)
White Stork.jpg
 
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